Immunogen
The antiserum was produced against synthesized peptide derived from human BMP-8. AA range:41-90
Specificity
BMP-8 Polyclonal Antibody detects endogenous levels of BMP-8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],
Function
function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8b entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Protein name
Bone morphogenetic protein 8A/B
Other name
BMP8B; BMP8; Bone morphogenetic protein 8B; BMP-8; BMP-8B; Osteogenic protein 2; OP-2; BMP8A; Bone morphogenetic protein 8A; BMP-8A
Fields
>>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Thermogenesis
Human protein sequence Database
P34820/Q7Z5Y6
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Hippocampus,Testis,
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