Immunogen
The antiserum was produced against synthesized peptide derived from human CRF. AA range:104-153
Specificity
CRF Polyclonal Antibody detects endogenous levels of CRF protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation a
Function
function:This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.,online information:Corticotropin-releasing hormone entry,similarity:Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.,
Protein name
Corticoliberin
Other name
CRH; Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Long-term depression;>>Cushing syndrome;>>Alcoholism
Human protein sequence Database
P06850
Mouse protein sequence database
Q8CIT0
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Produced by the hypothalamus and placenta.
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