Molecular weight (DA)
95kD
Immunogen
The antiserum was produced against synthesized peptide derived from human EFNA4. AA range:131-180
Specificity
Ephrin-A4 Polyclonal Antibody detects endogenous levels of Ephrin-A4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008],
Function
function:May play a role in the interaction between activated B lymphocytes and dendritic cells in tonsils.,similarity:Belongs to the ephrin family.,tissue specificity:Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.,
Other name
EFNA4; EPLG4; LERK4; Ephrin-A4; EPH-related receptor tyrosine kinase ligand 4; LERK-4
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>PI3K-Akt signaling pathway;>>Axon guidance;>>MicroRNAs in cancer
Human protein sequence Database
P52798
Mouse protein sequence database
O08542
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform 2]: Secreted .
Tissue expression
Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.
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