Molecular weight (DA)
19kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Neurophysin I. AA range:40-89
Specificity
Neurophysin I Polyclonal Antibody detects endogenous levels of Neurophysin I protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013],
Function
function:Neurophysin 1 specifically binds oxytocin.,function:Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.,online information:Oxytocin entry,pharmaceutical:Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor.,similarity:Belongs to the vasopressin/oxytocin family.,
Protein name
Oxytocin-neurophysin 1
Abbreviation
Neurophysin I
Other name
OXT; OT; Oxytocin-neurophysin 1; OT-NPI
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Oxytocin signaling pathway
Human protein sequence Database
P01178
Mouse protein sequence database
P35454
Rat protein sequence database
P01179
Cellular localization
Secreted.
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