Molecular weight (DA)
31kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TSG6. AA range:21-70
Specificity
TSG-6 Polyclonal Antibody detects endogenous levels of TSG-6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010],
Function
function:Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.,induction:By TNF.,similarity:Contains 1 CUB domain.,similarity:Contains 1 Link domain.,subunit:Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex.,tissue specificity:Found in the synovial fluid of patients with rheumatoid arthritis.,
Protein name
Tumor necrosis factor-inducible gene 6 protein
Other name
TNFAIP6; TSG6; Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6
Human protein sequence Database
P98066
Mouse protein sequence database
O08859
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level) (PubMed:16873769). Expressed in mesenchymal stem cells (PubMed:16771708). Found in the synovial fluid of patients with rheumatoid arthritis.
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