Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human EDN1. AA range:131-180
Specificity
ET-1 Polyclonal Antibody detects endogenous levels of ET-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p: 100-300.WB: 1/500 - 1/2000. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Function
function:Endothelins are endothelium-derived vasoconstrictor peptides.,online information:Endothelin entry,similarity:Belongs to the endothelin/sarafotoxin family.,tissue specificity:Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.,
Protein name
Endothelin-1
Other name
EDN1; Endothelin-1; Preproendothelin-1; PPET1
Fields
>>cAMP signaling pathway;>>HIF-1 signaling pathway;>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction;>>TNF signaling pathway;>>Melanogenesis;>>Renin secretion;>>Relaxin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Pathways in cancer;>>Hypertrophic cardiomyopathy;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P05305
Mouse protein sequence database
P22387
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.
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