Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human OGN. AA range:231-280
Specificity
Osteoglycin Polyclonal Antibody detects endogenous levels of Osteoglycin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Function
function:Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class III subfamily.,similarity:Contains 7 LRR (leucine-rich) repeats.,tissue specificity:Bone.,
Other name
OGN; OIF; SLRR3A; Mimecan; Osteoglycin; Osteoinductive factor; OIF
Human protein sequence Database
P20774
Mouse protein sequence database
Q62000
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix .
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