Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CX3CL1. AA range:231-280
Specificity
Fractalkine Polyclonal Antibody detects endogenous levels of Fractalkine protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.,induction:By TNF and IL-1 in pulmonary endothelial cells and umbilical vein endothelial cells.,online information:CX3CL1 entry,PTM:A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.,similarity:Belongs to the intercrine delta family.,subunit:Monomer.,tissue specificity:Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.,
Function
function:The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.,induction:By TNF and IL-1 in pulmonary endothelial cells and umbilical vein endothelial cells.,online information:CX3CL1 entry,PTM:A soluble short 95 kDa form may be released by proteolytic cleavage from the long membrane-anchored form.,similarity:Belongs to the intercrine delta family.,subunit:Monomer.,tissue specificity:Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas.,
Other name
CX3CL1; FKN; NTT; SCYD1; A-152E5.2; Fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>TNF signaling pathway;>>Human cytomegalovirus infection
Human protein sequence Database
P78423
Mouse protein sequence database
O35188
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .; [Processed fractalkine]: Secreted .
Tissue expression
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.
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