Molecular weight (DA)
11kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CCL11. AA range:41-90
Specificity
Eotaxin Polyclonal Antibody detects endogenous levels of Eotaxin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014],
Function
function:In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.,induction:By TNF-alpha, interleukin-1 alpha and interferon gamma.,online information:CCL11 entry,PTM:O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.,similarity:Belongs to the intercrine beta (chemokine CC) family.,
Other name
CCL11; SCYA11; Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>IL-17 signaling pathway;>>Asthma
Human protein sequence Database
P51671
Mouse protein sequence database
P48298
Rat protein sequence database
P97545
Cellular localization
Secreted .
Tissue expression
Blood,Foreskin,Lung,Placenta,Small intestine,
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