Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL6R. AA range:221-270
Specificity
IL-6Rα Polyclonal Antibody detects endogenous levels of IL-6Rα protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p: 100-300.WB: 1/500 - 1/2000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011],
Function
domain:The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.,function:Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.,PTM:A short soluble form may also be released from the membrane by proteolysis.,similarity:Belongs to the type I cytokine receptor family. Type 3 subfamily.,similarity:Contains 1 fibronectin type-III domain.,similarity:Contains 1 Ig-like C2-type (im
Protein name
Interleukin-6 receptor subunit alpha
Other name
IL6R; Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD126
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>HIF-1 signaling pathway;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Th17 cell differentiation;>>Non-alcoholic fatty liver disease;>>Human cytomegalovirus infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer
Human protein sequence Database
P08887
Mouse protein sequence database
P22272
Rat protein sequence database
Cellular localization
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .; [Soluble interleukin-6 receptor subunit alpha]: Secreted .
Tissue expression
[Isoform 2]: Expressed in peripheral blood mononuclear cells and weakly found in urine and serum. 1%-20% of the total sIL6R in plasma is generated by alternative splicing (PubMed:28060820).
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