Molecular weight (DA)
47kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human GDF7. AA range:321-370
Specificity
GDF-7 Polyclonal Antibody detects endogenous levels of GDF-7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016],
Function
function:May play an active role in the motor area of the primate neocortex.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Protein name
Growth/differentiation factor 7
Other name
GDF7; Growth/differentiation factor 7; GDF-7
Fields
>>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Axon guidance;>>Hippo signaling pathway
Human protein sequence Database
Q7Z4P5
Mouse protein sequence database
P43029
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Testis,
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