Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human NODAL. AA range:294-343
Specificity
Nodal Polyclonal Antibody detects endogenous levels of Nodal protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis. [provided by RefSeq, Aug 2016],
Function
disease:Defects in NODAL may be a cause of situs ambiguus [MIM:601265].,function:Essential for mesoderm formation and axial patterning during embryonic development.,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
Protein name
Nodal homolog
Other name
NODAL; Nodal homolog
Fields
>>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Signaling pathways regulating pluripotency of stem cells
Human protein sequence Database
Q96S42
Mouse protein sequence database
P43021
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Brain cortex,Fetal brain,
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