Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARF4. AA range:71-120
Specificity
ARF4 Polyclonal Antibody detects endogenous levels of ARF4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
ADP ribosylation factor 4(ARF4) Homo sapiens This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008],
Function
caution:Was originally thought to be ARF2.,function:GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.,similarity:Belongs to the small GTPase superfamily. Arf family.,
Protein name
ADP-ribosylation factor 4
Other name
ARF4; ARF2; ADP-ribosylation factor 4
Human protein sequence Database
P18085
Mouse protein sequence database
P61750
Rat protein sequence database
Cellular localization
Golgi apparatus. Membrane ; Lipid-anchor .
Tissue expression
Bone marrow,Brain,Cerebellum,Placenta,Skin,Urinary bladder,
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