Immunogen
Synthesized peptide derived from Rab 24 . at AA range: 90-170
Specificity
Rab 24 Polyclonal Antibody detects endogenous levels of Rab 24 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ,IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009],
Function
function:May be involved in autophagy-related processes.,induction:By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).,miscellaneous:The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP.,PTM:Isoprenylation is inefficient compared to other Rab family members.,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Only about 20-25% is recovered in the particulate fraction.,subunit:Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB.,
Protein name
Ras-related protein Rab-24
Other name
RAB24; Ras-related protein Rab-24
Human protein sequence Database
Q969Q5
Mouse protein sequence database
P35290
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Membrane ; Lipid-anchor . Only about 20-25% is recovered in the particulate fraction. .
Tissue expression
Amygdala,Pancreas,Skin,Uterus,Whole embryo,
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