Molecular weight (DA)
44kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RRAGC. AA range:302-351
Specificity
Rag C Polyclonal Antibody detects endogenous levels of Rag C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; IP 1:50-200 ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
Function
function:Has guanine nucleotide-binding activity but weak intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.,subunit:Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB.,
Protein name
Ras-related GTP-binding protein C
Other name
RRAGC; Ras-related GTP-binding protein C; Rag C; RagC; GTPase-interacting protein 2; TIB929
Fields
>>Autophagy - animal;>>mTOR signaling pathway;>>Shigellosis
Human protein sequence Database
Q9HB90
Mouse protein sequence database
Q99K70
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). .
Tissue expression
Lymph,Ovary,
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