Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RASSF4. AA range:134-183
Specificity
RASSF4 Polyclonal Antibody detects endogenous levels of RASSF4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The function of this gene has not yet been determined but may involve a role in tumor suppression. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described. [provided by RefSeq, Jul 2008],
Function
function:Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,subunit:Interacts directly with activated KRAS in a GTP-dependent manner.,tissue specificity:Widely expressed. Frequently down-regulated in tumor cell lines.,
Protein name
Ras association domain-containing protein 4
Other name
RASSF4; AD037; Ras association domain-containing protein 4
Fields
>>Hippo signaling pathway - multiple species
Human protein sequence Database
Q9H2L5
Mouse protein sequence database
Q8CB96
Rat protein sequence database
Q566C5
Tissue expression
Widely expressed. Frequently down-regulated in tumor cell lines.
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