Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARHGEF3. AA range:456-505
Specificity
XPLN Polyclonal Antibody detects endogenous levels of XPLN protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,subunit:Interacts with RHOA and RHOB.,tissue specificity:Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.,
Protein name
Rho guanine nucleotide exchange factor 3
Other name
ARHGEF3; Rho guanine nucleotide exchange factor 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN
Human protein sequence Database
Q9NR81
Mouse protein sequence database
Q91X46
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
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