Molecular weight (DA)
97kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CLCN6. AA range:611-660
Specificity
CLC-6 Polyclonal Antibody detects endogenous levels of CLC-6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
chloride voltage-gated channel 6(CLCN6) Homo sapiens This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012],
Function
function:Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.,miscellaneous:The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.,PTM:N-glycosylated on several asparagine residues.,similarity:Belongs to the chloride channel (TC 2.A.49) family.,similarity:Contains 2 CBS domains.,subcellular location:Detected in detergent-resistant lipid rafts.,tissue specificity:Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney.,
Protein name
Chloride transport protein 6
Other name
CLCN6; KIAA0046; Chloride transport protein 6; Chloride channel protein 6; ClC-6
Human protein sequence Database
P51797
Mouse protein sequence database
O35454
Rat protein sequence database
Cellular localization
Late endosome membrane ; Multi-pass membrane protein .
Tissue expression
Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney.
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