Molecular weight (DA)
83kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CNGA2. AA range:391-440
Specificity
CNG-2 Polyclonal Antibody detects endogenous levels of CNG-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010],
Function
function:Odorant signal transduction is probably mediated by a G-protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons.,similarity:Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.,similarity:Contains 1 cyclic nucleotide-binding domain.,
Protein name
Cyclic nucleotide-gated olfactory channel
Other name
CNGA2; CNCA; CNCA1; CNCG2; Cyclic nucleotide-gated olfactory channel; Cyclic nucleotide-gated cation channel 2; Cyclic nucleotide-gated channel alpha-2; CNG channel alpha-2; CNG-2; CNG2
Fields
>>cAMP signaling pathway;>>Olfactory transduction
Human protein sequence Database
Q16280
Mouse protein sequence database
Q62398
Rat protein sequence database
Q00195
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Testis,
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