Molecular weight (DA)
110kD
Immunogen
The antiserum was produced against synthesized peptide derived from human KCNH1. AA range:720-769
Specificity
KCNH1 Polyclonal Antibody detects endogenous levels of KCNH1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided
Function
disease:Overexpression of EAG may confer a growth advantage to cancer cells and favor tumor cell proliferation.,domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with K
Protein name
Potassium voltage-gated channel subfamily H member 1
Other name
KCNH1; EAG; EAG1; Potassium voltage-gated channel subfamily H member 1; Ether-a-go-go potassium channel 1; EAG channel 1; h-eag; hEAG1; Voltage-gated potassium channel subunit Kv10.1
Human protein sequence Database
O95259
Mouse protein sequence database
Q60603
Rat protein sequence database
Q63472
Cellular localization
Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Perikaryon . Cell junction, synapse, postsynaptic density membrane . Early endosome membrane . Perinuclear KCNH1 is located to NPC-free islands.
Tissue expression
Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
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