Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human KCNJ4. AA range:251-300
Specificity
KIR2.3 Polyclonal Antibody detects endogenous levels of KIR2.3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
Function
domain:The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation properties.,function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Homomultimeric and heteromultimeric association with Kir2.1, resulting in an enhanced G-protein-induced current. Association, via its PDZ-recognition domain, with LIN7A, LIN7B,
Protein name
Inward rectifier potassium channel 4
Other name
KCNJ4; IRK3; Inward rectifier potassium channel 4; HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel; inwardly rectifying subfamily J member 4
Fields
>>Cholinergic synapse;>>Oxytocin signaling pathway
Human protein sequence Database
P48050
Mouse protein sequence database
P52189
Rat protein sequence database
P52190
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane . TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization. .
Tissue expression
Heart, skeletal muscle, and several different brain regions including the hippocampus.
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