Molecular weight (DA)
44kD
Immunogen
The antiserum was produced against synthesized peptide derived from human KCNJ9. AA range:61-110
Specificity
KIR3.3 Polyclonal Antibody detects endogenous levels of KIR3.3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008],
Function
function:This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.,similarity:Belongs to the inward rectifier-type potassium channel family.,subunit:Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit.,
Protein name
G protein-activated inward rectifier potassium channel 3
Other name
KCNJ9; GIRK3; G protein-activated inward rectifier potassium channel 3; GIRK-3; Inward rectifier K(+) channel Kir3.3; Potassium channel; inwardly rectifying subfamily J member 9
Fields
>>Circadian entrainment;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>Dopaminergic synapse;>>Estrogen signaling pathway;>>Oxytocin signaling pathway;>>GnRH secretion;>>Morphine addiction
Human protein sequence Database
Q92806
Mouse protein sequence database
P48543
Rat protein sequence database
Q63511
Cellular localization
Membrane; Multi-pass membrane protein.
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