Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SLC9A8. AA range:451-500
Specificity
NHE-8 Polyclonal Antibody detects endogenous levels of NHE-8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009],
Function
function:Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,tissue specificity:Ubiquitous. Strongly expressed in skeletal muscle and kidney.,
Protein name
Sodium/hydrogen exchanger 8
Other name
SLC9A8; KIAA0939; NHE8; Sodium/hydrogen exchanger 8; Na(+)/H(+) exchanger 8; NHE-8; Solute carrier family 9 member 8
Human protein sequence Database
Q9Y2E8
Mouse protein sequence database
Q8R4D1
Rat protein sequence database
Q4L208
Cellular localization
Golgi apparatus membrane ; Multi-pass membrane protein .
Tissue expression
Ubiquitous. Strongly expressed in skeletal muscle and kidney.
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