Immunogen
Purified recombinant fragment of human CDC25C expressed in E. Coli.
Specificity
CDC25C Monoclonal Antibody detects endogenous levels of CDC25C protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
cell division cycle 25C(CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015],
Function
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed predominantly in G2 phase.,function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.,similarity:Belongs to the MPI phosphatase family.,similarity:Contains 1 rhodanese domain.,subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.,
Protein name
M-phase inducer phosphatase 3
Other name
CDC25C; M-phase inducer phosphatase 3; Dual specificity phosphatase Cdc25C
Fields
>>Cell cycle;>>Oocyte meiosis;>>Progesterone-mediated oocyte maturation;>>Human immunodeficiency virus 1 infection;>>MicroRNAs in cancer
Human protein sequence Database
P30307
Mouse protein sequence database
P48967
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Colon carcinoma,Epithelium,Skin,Testis,
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