Molecular weight (DA)
44kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDC37. AA range:1-50
Specificity
Cdc37 Polyclonal Antibody detects endogenous levels of Cdc37 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],
Function
function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,
Protein name
Hsp90 co-chaperone Cdc37
Other name
CDC37; CDC37A; Hsp90 co-chaperone Cdc37; Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37
Fields
>>PI3K-Akt signaling pathway
Human protein sequence Database
Q16543
Mouse protein sequence database
Q61081
Rat protein sequence database
Q63692
Cellular localization
Cytoplasm .
Tissue expression
Lymph,Placenta,
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