Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from Cdc37L1 . at AA range: 80-160
Specificity
Cdc37L1 Polyclonal Antibody detects endogenous levels of Cdc37L1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008],
Function
function:Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.,sequence caution:Translated as Cys.,similarity:Belongs to the CDC37 family.,subunit:Self-associates. Forms complexes with Hsp70 and Hsp90. Interacts with CDC37, FKBP4, PPID and STIP1.,tissue specificity:Expressed in brain, heart, kidney, liver, placenta and skeletal muscle.,
Protein name
Hsp90 co-chaperone Cdc37-like 1
Other name
CDC37L1; CDC37B; HARC; Hsp90 co-chaperone Cdc37-like 1; Hsp90-associating relative of Cdc37
Human protein sequence Database
Q7L3B6
Mouse protein sequence database
Q9CZP7
Rat protein sequence database
Q5XIC3
Cellular localization
Cytoplasm .
Tissue expression
Expressed in brain, heart, kidney, liver, placenta and skeletal muscle.
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