Molecular weight (DA)
90kD
Immunogen
Synthesized peptide derived from Cdk11A/B . at AA range: 190-270
Specificity
Cdk11A/B Polyclonal Antibody detects endogenous levels of Cdk11A/B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,
Protein name
Cell division protein kinase 11A/B
Other name
CDK11A; CDC2L2; CDC2L3; PITSLREB; Cyclin-dependent kinase 11A; Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11A; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase C
Human protein sequence Database
Q9UQ88/P21127
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus.
Tissue expression
Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
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