Molecular weight (DA)
66kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RED. AA range:508-557
Specificity
IK Polyclonal Antibody detects endogenous levels of IK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008],
Function
caution:Was originally (PubMed:7970704) thought to be the IK factor, a cytokine involved in the negative regulatory pathway of constitutive MHC class II antigens expression.,developmental stage:Expressed at similar levels in fetal and adult tissues.,function:Not known. May bind to chromatin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RED family.,tissue specificity:Ubiquitous.,
Other name
IK; RED; RER; Protein Red; Cytokine IK; IK factor; Protein RER
Human protein sequence Database
Q13123
Mouse protein sequence database
Q9Z1M8
Rat protein sequence database
Q66HG8
Cellular localization
Nucleus . Nucleus, nucleoplasm . Chromosome . Cytoplasm, cytoskeleton, spindle pole . Predominantly present throughout the nucleoplasm during prometaphase, metaphase and anaphase. Is also detected in nuclear foci that are not identical with Cajal bodies. Starts to accumulate at chromosomes during telophase, and is nearly exclusively associated with chromosomes in newly divided cells (PubMed:24252166). Colocalizes with MAD1L1 at mitotic spindle poles during metaphase and anaphase (PubMed:22351768). .
Tissue expression
Ubiquitous.
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