Molecular weight (DA)
92kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDC2L1. AA range:10-59
Specificity
PITSLRE Polyclonal Antibody detects endogenous levels of PITSLRE protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,
Protein name
Cyclin-dependent kinase 11B
Other name
CDK11B; CDC2L1; CDK11; PITSLREA; PK58; Cyclin-dependent kinase 11B; Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-prot
Human protein sequence Database
P21127
Mouse protein sequence database
P24788
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus.
Tissue expression
Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.
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