Immunogen
Purified recombinant fragment of CD18 expressed in E. Coli.
Specificity
CD18 Monoclonal Antibody detects endogenous levels of CD18 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Function
disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on S
Protein name
Integrin beta-2
Other name
ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150; 95 subunit beta; Complement receptor C3 subunit beta; CD antigen CD18
Fields
>>Rap1 signaling pathway;>>Phagosome;>>Hippo signaling pathway;>>Cell adhesion molecules;>>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Natural killer cell mediated cytotoxicity;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Pertussis;>>Legionellosis;>>Leishmaniasis;>>Malaria;>>Amoebiasis;>>Staphylococcus aureus infection;>>Tuberculosis;>>Human T-cell leukemia virus 1 infection;>>Rheumatoid arthritis;>>Viral myocarditis
Human protein sequence Database
P05107
Mouse protein sequence database
P11835
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
Tissue expression
Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车