Molecular weight (DA)
23kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 6 around the phosphorylation site of Tyr219. AA range:171-220
Specificity
Phospho-Claudin-6 (Y219) Polyclonal Antibody detects endogenous levels of Claudin-6 protein only when phosphorylated at Y219.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010],
Function
function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
Other name
CLDN6; Claudin-6; Skullin
Fields
>>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C
Human protein sequence Database
P56747
Mouse protein sequence database
Q9Z262
Rat protein sequence database
Cellular localization
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
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