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Cadherin-8 Polyclonal Antibody

Polyclonal antibody

Specification

BYab-16936

  • 50UL $180 100UL $255
  • Delivery: In Stock

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Host
Reactiveness
Use
Molecular weight (DA)
90kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDH8. AA range:491-540
Specificity
Cadherin-8 Polyclonal Antibody detects endogenous levels of Cadherin-8 protein.
Source
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Background
This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008],
Function
function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.,
Gene Name
CDH8
Protein name
Cadherin-8
Abbreviation
Cadherin-8
Other name
CDH8; Cadherin-8
Fields
Human gene ID
1006
Human protein sequence Database
P55286
Mouse gene ID
12564
Mouse protein sequence database
P97291
Rat gene ID
Rat protein sequence database
O54800
Cellular localization
Cell membrane; Single-pass type I membrane protein.
Tissue expression
Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.
Storage
-20°C/1 year

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Cadherin-8 Polyclonal Antibody

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