Molecular weight (DA)
25kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 2. AA range:181-230
Specificity
Claudin-2 Polyclonal Antibody detects endogenous levels of Claudin-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],
Function
function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
Other name
CLDN2; PSEC0059; SP82; Claudin-2; SP82
Fields
>>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C
Human protein sequence Database
P57739
Mouse protein sequence database
O88552
Rat protein sequence database
Cellular localization
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
Tissue expression
Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,
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