Immunogen
Synthesized peptide derived from human C-ternal NUPR1
Specificity
This antibody detects endogenous levels of NUPR1 at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses . Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A . Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation . Negatively regulates apoptosis through interaction with PTMA . Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOX
Protein name
Nuclear protein 1 (Candidate of metastasis 1) (Protein p8)
Other name
Nuclear protein 1 (Candidate of metastasis 1) (Protein p8)
Human protein sequence Database
O60356
Mouse protein sequence database
Q9WTK0
Rat protein sequence database
O54842
Cellular localization
Nucleus . Cytoplasm . Cytoplasm, perinuclear region .
Tissue expression
Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes.
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