Immunogen
Synthesized peptide derived from human N-ternal SYG
Specificity
This antibody detects endogenous levels of SYG at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) . Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis .
Protein name
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)
Other name
Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)
Human protein sequence Database
P41250
Mouse protein sequence database
Q9CZD3
Rat protein sequence database
Q5I0G4
Cellular localization
Cytoplasm . Cell projection, axon . Secreted . Secreted, extracellular exosome . In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524). Secreted by motor neuron, possibly through the exosome pathway (By similarity). .; [Isoform 1]: Mitochondrion . Cytoplasm .; [Isoform 2]: Cytoplasm . Cell projection, axon .
Tissue expression
Widely expressed, including in brain and spinal cord. ; [Isoform 2]: Expressed in brain, spinal cord, muscle, heart and spleen. ; [Isoform 1]: Expressed in brain, spinal cord, muscle, heart, spleen and liver.
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