Immunogen
Synthesized peptide derived from human C-ternal CUL9
Specificity
This antibody detects endogenous levels of CUL9 at Human, Mouse
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 . Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function .
Gene Name
CUL9 H7AP1 KIAA0708 PARC
Protein name
Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
Other name
Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
Human protein sequence Database
Q8IWT3
Mouse protein sequence database
Q80TT8
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Ubiquitously expressed in all tissues with highest expression in testis brain and kidney.
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