Immunogen
Synthesized peptide derived from human N-ternal YTDC1
Specificity
This antibody detects endogenous levels of YTDC1 at Human,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate
Gene Name
YTHDC1 KIAA1966 YT521
Protein name
YTH domain-containing protein 1 (Putative splicing factor YT521)
Other name
YTH domain-containing protein 1 (Putative splicing factor YT521)
Human protein sequence Database
Q96MU7
Mouse protein sequence database
Rat protein sequence database
Q9QY02
Cellular localization
Nucleus . Nucleus speckle . Localizes to a novel subnuclear structure, the YT bodies. .
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