Immunogen
Synthesized peptide derived from human C-ternal P2RX7
Specificity
This antibody detects endogenous levels of P2RX7 at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells .
Protein name
P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)
Other name
P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)
Human protein sequence Database
Q99572
Mouse protein sequence database
Q9Z1M0
Rat protein sequence database
Q64663
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed with highest levels in brain and immune tissues.
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