Molecular weight (DA)
36kD
Immunogen
Synthesized peptide derived from human KCTD12
Specificity
This antibody detects endogenous levels of KCTD12 at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.305% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Gene Name
KCTD12 C13orf2 KIAA1778 PFET1
Protein name
BTB/POZ domain-containing protein KCTD12 (Pfetin) (Predominantly fetal expressed T1 domain)
Human protein sequence Database
Q96CX2
Mouse protein sequence database
Q6WVG3
Rat protein sequence database
Cellular localization
Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane .
Tissue expression
Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.
Storage
‘-15°C to -25°C/1 year(Do not lower than -25°C)
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