Molecular weight (DA)
Molecular Weight
Calculated MW: 36 kDa;Observed MW:39kDa
Clonality
Immunogen
A synthesized peptide derived from human Phospho-IKB alpha (S36)
Dilution rate
WB: 1/500-1/1000 FC: 1/50
Purification process (Immunogen)
Background
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Other name
I kappa B alpha; IkappaBalpha; IkB-alpha; IKBA; IKBalpha; MAD3; NF kappa B inhibitor alpha; NFKBI; NFKBIA;
Human gene ID
SwissProt ID
P25963
Human protein sequence Database
Gene ID
4792
Mouse protein sequence database
Rat protein sequence database
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.