Molecular weight (DA)
Molecular Weight
Calculated MW: 54 kDa; Observed MW: 54 kDa
Immunogen
A synthesized peptide derived from human MLKL
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100
Purification process (Immunogen)
Background
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma
membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane
damage. Does not have protein kinase activity.
Human gene ID
SwissProt ID Q8NB16
Human protein sequence Database
Gene ID
197259
Mouse protein sequence database
Rat protein sequence database
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.