Molecular weight (DA)
281kD
Immunogen
Synthesized peptide derived from human USP9X
Specificity
This antibody detects endogenous levels of USP9X at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins . May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin . Specifically hydrolyzes 'Lys-63'-, 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains . Essential component of TGF-beta/BMP signaling cascade . Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33 . Deubiquitinates alkylation repair enzyme ALKBH3 . OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions . Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembl
Gene Name
USP9X DFFRX FAM USP9
Protein name
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X)
Human protein sequence Database
Q93008
Mouse protein sequence database
P70398
Rat protein sequence database
Cellular localization
Cytoplasm . Cell projection, growth cone . Cytoplasm, cytoskeleton, cilium axoneme .
Tissue expression
Widely expressed in embryonic and adult tissues.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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