Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from human TMEM175
Specificity
This antibody detects endogenous levels of TMEM175 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes . Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion . Constitutes the major lysosomal potassium channel . Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors . The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation . The lysoK(GF) complex is required to protect neurons against stress-induced damage .
Protein name
Transmembrane protein 175
Human protein sequence Database
Q9BSA9
Mouse protein sequence database
Q9CXY1
Rat protein sequence database
Q6AY05
Cellular localization
Endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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