Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from human PLAG1
Specificity
This antibody detects endogenous levels of PLAG1 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
Protein name
Zinc finger protein PLAG1 (Pleiomorphic adenoma gene 1 protein)
Human protein sequence Database
Q6DJT9
Mouse protein sequence database
Q9QYE0
Rat protein sequence database
Q5U2T6
Cellular localization
Nucleus . Strong nucleolar localization when sumoylation is inhibited.
Tissue expression
Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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