Molecular weight (DA)
Molecular Weight
Calculated MW: 20 kDa; Observed MW: 20 kDa
Immunogen
Synthetic peptide of human IL7
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100
Purification process (Immunogen)
Background
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.
Other name
IL-7; interleukin 7
Human gene ID
SwissProt ID
P13232
Human protein sequence Database
Gene ID
3574
Mouse protein sequence database
Rat protein sequence database
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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