Molecular weight (DA)
18kD
Immunogen
Synthesized peptide derived from human FLAP
Specificity
This antibody detects endogenous levels of FLAP at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Protein name
Arachidonate 5-lipoxygenase-activating protein (FLAP) (MK-886-binding protein)
Human protein sequence Database
P20292
Mouse protein sequence database
P30355
Rat protein sequence database
P20291
Cellular localization
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)