Molecular weight (DA)
31kD
Immunogen
Synthesized peptide derived from human TMEM119
Specificity
This antibody detects endogenous levels of TMEM119 at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts . May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity).
Gene Name
TMEM119 PSEC0199 UNQ731/PRO1415
Protein name
Transmembrane protein 119
Human protein sequence Database
Q4V9L6
Mouse protein sequence database
Q8R138
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Endoplasmic reticulum membrane .
Tissue expression
Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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