Molecular weight (DA)
11kD
Immunogen
Synthesized peptide derived from human TIMM8A
Specificity
This antibody detects endogenous levels of TIMM8A at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
Gene Name
TIMM8A DDP DDP1 TIM8A
Protein name
Mitochondrial import inner membrane translocase subunit Tim8 A (Deafness dystonia protein 1) (X-linked deafness dystonia protein)
Human protein sequence Database
O60220
Mouse protein sequence database
Q9WVA2
Rat protein sequence database
Q9WVA1
Cellular localization
Mitochondrion inner membrane ; Peripheral membrane protein ; Intermembrane side .
Tissue expression
Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车