Molecular weight (DA)
55kD
Immunogen
Synthesized peptide derived from human TRIM22
Specificity
This antibody detects endogenous levels of TRIM22 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
Gene Name
TRIM22 RNF94 STAF50
Protein name
E3 ubiquitin-protein ligase TRIM22 (EC 6.3.2.-) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (Staf-50) (Tripartite motif-containing protein 22)
Human protein sequence Database
Q8IYM9
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Nucleus speckle. Nucleus, Cajal body. Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
Tissue expression
Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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