Molecular weight (DA)
108kD
Immunogen
Synthesized peptide derived from human RAI14
Specificity
This antibody detects endogenous levels of RAI14 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
Gene Name
RAI14 KIAA1334 NORPEG
Protein name
Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)
Human protein sequence Database
Q9P0K7
Mouse protein sequence database
Q9EP71
Rat protein sequence database
Q5U312
Cellular localization
Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, stress fiber . Cytoplasm, cell cortex . Cell junction . Nucleus . Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites (By similarity). Highly expressed at the ectoplasmic specialization, an actin-rich cell junction specific to the testis (By similarity). Predominantly nuclear in nonconfluent cells (PubMed:16729964). .
Tissue expression
Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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